Hemoglobin

Description

The primary aim of this book is to provide a synthesis of our current understanding of hemoglobin function and evolution, and to illustrate how research on one particular family of proteins has provided general insights into mechanisms of protein evolution and biochemical adaptation. In doing so, it will also promote an appreciation of how mechanistic insights into protein function can enrich our understanding of how evolution works. Reciprocally, it highlights how approaches in evolutionary genetics (such as phylogenetic comparative methods and ancestral sequence reconstruction) can be brought to bear on questions about the functional evolution of proteins. This treatise on the functional evolution of hemoglobin illustrates how research on a single, well-chosen model system can enhance our investigative acuity and bring key conceptual questions into especially sharp focus.

About the author

Jay Storz is the Susan J. Rosowski Professor of Biology at the University of Nebraska. His research is motivated by questions about mechanisms of protein evolution, gene family evolution, and the genetic basis of biochemical and physiological adaptation. Professor Storz's work is supported by the National Institutes of Health and the National Science Foundation.

Table of contents

1:Principles of protein structure
2:A study in scarlet: The role of hemoglobin in blood gas transport
3:Allosteric theory
4:Hemoglobin structure and allosteric mechanism
5:Evolution of the vertebrate globin gene family
6:Gene duplication and hemoglobin isoform differentiation
7:The evolution of novel hemoglobin functions and physiological innovation
8:Mechanisms of biochemical adaptation to environmental hypoxia
9:Darwin's molecule: Evolutionary insights into mechanisms of biochemical adaptation and protein evolution