An Introduction to Medicinal Chemistry

Price: 1030.00 INR

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ISBN:

9780198796589

Publication date:

30/01/2018

Paperback

800 pages

265.0x195.0mm

Price: 1030.00 INR

We sell our titles through other companies
Disclaimer :You will be redirected to a third party website.The sole responsibility of supplies, condition of the product, availability of stock, date of delivery, mode of payment will be as promised by the said third party only. Prices and specifications may vary from the OUP India site.

ISBN:

9780198796589

Publication date:

30/01/2018

Paperback

800 pages

265.0x195.0mm

Sixth Edition

Graham Patrick

Accessible and clear, this new International Edition of An Introduction to Medicinal Chemistry is the ideal text for students encountering the subject for the first time. Complete coverage of the subject is augmented by extensive pedagogical support and opportunities for students to hone their problem solving skills.

Rights:  World Rights

Sixth Edition

Graham Patrick

Description

For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actually work? Furthermore, by what processes are new drugs discovered and brought to market?

An Introduction to Medicinal Chemistry, International Edition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Part A of the book introduces the principles of drug action via targets such as receptors and enzymes. The book goes on to explore how drugs work at the molecular level (pharmacodynamics), and the processes involved in ensuring a drug meets its target (pharmacokinetics). Further sections cover the processes by which drugs are discovered and designed, and what has to happen before a drug can be made available to the public. The book concludes with a selection of current topics in medicinal chemistry, and a discussion of various key drug groups. The subject is brought to life throughout by engaging case studies highlighting particular drugs and the stories behind their discovery and development.

Sixth Edition

Graham Patrick

Table of contents

  1. Drugs and drug targets: an overview

Part A - Drug Targets, Pharmacodynamics and Pharmacokinetics
  1. Protein structure and function
  2. Enzymes and enzyme inhibitors
  3. Receptors, agonists and antagonists
  4. Receptors and signal transduction
  5. Nucleic acids as drug targets
  6. Miscellaneous drug targets
  7. Pharmacokinetics and related topics

Part B - Drug Discovery, Design, and Development
  1. Drug discovery: finding a lead
  2. Drug design: optimizing target interactions
  3. Drug design: optimizing access to the target
  4. Getting the drug to market

Part C - Selected Topics in Medicinal Chemistry
  1. Cholinergics, anticholinergics, and anticholinesterases
  2. Drugs acting on the adrenergic nervous system
  3. Opioid analgesics
  4. Antiulcer agents
  5. Antibacterial agents
  6. Antiviral agents
  7. Anticancer agents

Part D - Tools of the Trade
  1. Combinatorial synthesis
  2. Computers in medicinal chemistry
  3. Quantitative structure-activity relationships (QSAR)

Sixth Edition

Graham Patrick

Features

  • Clear and accessible writing style makes the text ideal for those new to the subject
  • Frequent boxes and case studies help students to link the underlying theory to its pharmaceutical application
  • Numerous questions and activities both throughout the book and on the accompanying website help students hone their problem solving skills
  • Well-developed pedagogy - including frequent key point sections - support students in their learning


New to this Edition:
  • Coverage of molecular biology topics such as signalling pathways provide extra support for those students who haven't previously encountered these topics.
  • Molecular modelling problems in Chem3D on the Online Resource Centre allows students to practice their molecular modelling skills using freely-available software.


For students:
  • Multiple choice questions to support self-directed learning
  • Web articles describing recent developments in the field and further information on topics covered in the book
  • Journal Club to encourage students to critically analyse the research literature
  • Molecular modelling exercises, with new exercises in Chem3D
  • New assignments to help students develop data analysis and problem solving skills
  • Further reading
  • Glossary of terms included in the book


For registered adopters of the book:
  • A test bank of additional multiple-choice questions
  • Answers to end-of-chapter questions
  • Figures from the book, ready to download
  • Power Point slides to accompany every chapter in the book
  • Appendices providing more information on topics covered in the book

Sixth Edition

Graham Patrick

Review

'It is by far the best book on the market for medicinal chemistry and drug discovery. ' (Professor Steven Bull, University of Bath )

'Summarizes the chemistry of medicinal agents in a manner that easily facilitates understanding of the core principles in the context of pharmacological drug action and clinical therapeutics. ' (Professor John Marriott, University of Birmingham )

Sixth Edition

Graham Patrick

Description

For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actually work? Furthermore, by what processes are new drugs discovered and brought to market?

An Introduction to Medicinal Chemistry, International Edition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Part A of the book introduces the principles of drug action via targets such as receptors and enzymes. The book goes on to explore how drugs work at the molecular level (pharmacodynamics), and the processes involved in ensuring a drug meets its target (pharmacokinetics). Further sections cover the processes by which drugs are discovered and designed, and what has to happen before a drug can be made available to the public. The book concludes with a selection of current topics in medicinal chemistry, and a discussion of various key drug groups. The subject is brought to life throughout by engaging case studies highlighting particular drugs and the stories behind their discovery and development.

Read More

Reviews

'It is by far the best book on the market for medicinal chemistry and drug discovery. ' (Professor Steven Bull, University of Bath )

'Summarizes the chemistry of medicinal agents in a manner that easily facilitates understanding of the core principles in the context of pharmacological drug action and clinical therapeutics. ' (Professor John Marriott, University of Birmingham )

Read More

Table of contents

  1. Drugs and drug targets: an overview

Part A - Drug Targets, Pharmacodynamics and Pharmacokinetics
  1. Protein structure and function
  2. Enzymes and enzyme inhibitors
  3. Receptors, agonists and antagonists
  4. Receptors and signal transduction
  5. Nucleic acids as drug targets
  6. Miscellaneous drug targets
  7. Pharmacokinetics and related topics

Part B - Drug Discovery, Design, and Development
  1. Drug discovery: finding a lead
  2. Drug design: optimizing target interactions
  3. Drug design: optimizing access to the target
  4. Getting the drug to market

Part C - Selected Topics in Medicinal Chemistry
  1. Cholinergics, anticholinergics, and anticholinesterases
  2. Drugs acting on the adrenergic nervous system
  3. Opioid analgesics
  4. Antiulcer agents
  5. Antibacterial agents
  6. Antiviral agents
  7. Anticancer agents

Part D - Tools of the Trade
  1. Combinatorial synthesis
  2. Computers in medicinal chemistry
  3. Quantitative structure-activity relationships (QSAR)

Read More